Sign of Leser-Trélat. Authoritative facts about the skin from DermNet New Zealand. Leser-Trélat sign is a rare skin condition characterized by the sudden appearance of seborrheic keratoses that rapidly increase in number and size within weeks. Images in Clinical Medicine from The New England Journal of Medicine — The Sign of Leser–Trélat.

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The sign of Leser-Trelat. They are well-circumscribed pigmented lesions with the color ranging from skin tone to tan or brown, and some lesions may appear black. Leser Trelat Sign – StatPearls. A case report and review trelwt the literature.

Leser–Trélat sign – Wikipedia

Various subtypes of seborrheic keratoses exist including acanthotic most common varianthyperkeratotic, reticulated, clonal and melanoacanthoma. Sign in to download free article PDFs Sign in to access your subscriptions Sign in to your personal account. Indian J Dermatol Venereol Leprol. The typical morphology of these lesions tends to vary extensively amongst patients and may present as a macule, papules, and plaques.

It is caused by an associated cancer and often occurs with malignant acanthosis nigricans. Any of these distinct variations may also trelt irritated or inflamed, displaying either squamous eddy formation spindled cells or lymphocyte infiltration, respectively. Retrieved from ” https: It trelag thought that paraneoplastic syndromes are caused by the release of hormones from the tumour but this remains to be proven.


Febrile neutrophilic dermatosis Pyoderma gangrenosum Paraneoplastic pemphigus. Two months before, she had noticed the sudden appearance of many “warts” on her face and neck. J Am Acad Dermatol. CA Cancer J Clin. They appear as brown warty nodules with a stuck-on appearance. Self-skin examination New smartphone apps to check your skin Learn more Sponsored content.

Ueber ein die Krebskrankheit beim Menschen haufig begleitendes, noch wenig gekanntes Symptom. A possible role of a cutaneous marker for internal malignancy. Click on image for details. History and Physical As previously mentioned, seborrheic keratoses are a nearly ubiquitous, benign skin lesion in patients greater than 40 years of age. It may possibly be due to the same unknown factors that induce malignant acanthosis nigricans.

Gharwan H, Gradon JD. Purchase access Subscribe to the journal. Privacy Policy Terms of Use. Differential Diagnosis Eruptive seborrheic keratoses have been reported in numerous other clinical scenarios including in telat with erythroderma, pregnant patients, HIV-infected patients, and transplant patients.

Sign of Leser-Trélat

Additional named growth factors include human-growth-hormone, transforming growth factor-alpha, and insulin-like growth factor. Safa G, Darrieux L. Aldrich-Mees’ lines Beau’s lines Muehrcke’s lines Terry’s nails. The presence of horn cysts on the leeer of the lesions is also classic. This book is distributed under the terms of the Creative Commons Attribution 4. To access free multiple choice questions on this topic, click here.

Dermatologic signs Paraneoplastic syndromes. Get free access to newly published articles Create a personal account or sign in to: However, given the abrupt onset of the seborrheic keratoses and their distinctive appearance misdiagnosis as another cutaneous entity would be unlikely.


The primary aim of treatment is to treat the underlying cancer.

Show details Treasure Island FL: The Oxford illustrated companion to medicine. There does not appear to be an increased frequency of a specific histopathological variation of seborrheic keratoses that correlates with the sign of Leser-Trelat. Russell bodies Auer rod Bence Jones protein.

J Am Acad Dermatol ; Retrieved 15 July Online since 15 th March ‘ On physical examination, multiple, 2- to 6-mm, seborrheic keratoses and numerous pigmented filariform papillomas were present on the neck and malar sifn Figure. From Wikipedia, the free encyclopedia. Cutaneous paraneoplastic syndromes in solid tumors. Create a lesfr personal account to download free article PDFs, sign up for alerts, and more.

Malignant involvement of the skin and the genodermatoses. Eponymous medical signs for oncology.

The associated cancer is often advanced and the average survival of these patients is approximately Clear Turn Off Turn On. Both the neoplastic and paraneoplastic process began concurrently. StatPearls Publishing; Jan.