Objective: We performed a systematic review and meta-analysis of published demiological studies of developmental fluo-. ride neurotoxicity. Developmental Fluoride Neurotoxicity: Choi et al. Respond . fluoride neurotoxicity: a systematic review and meta-. analysis. Environ Health. “Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis” is a study published in Environmental Health.

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Children had lower IQ scores in high-fluoride area than those who lived in the reference area. Children living in high-fluoride and -arsenic area had significantly lower Developmentao scores than those living in the reference fluoride and no arsenic area. Measurement of intelligence by drawing test among the children in the endemic area of Al-F combined toxicosis.

For concerns on copyright infringement please see: Reference lists of included articles were also searched. J Occup Health Damage. However, if you actually read the paper and look at Table 1, the study compared children in areas with recommended levels of fluoride in water — the same levels that are introduced in the process of water fluoridation 0.

Use of materials published in EHP should be acknowledged for example,? From the geographic distribution of the studies, it seems unlikely that fluoride-attributed neurotoxicity could be attributable to other water contaminants. In many rural communities in China, populations with high exposure to fluoride in local drinking-water sources may reside in close proximity to populations without high exposure NRC Received Dec 30; Accepted Jul Studies were combined in suitable meta-analyses.

Two of the studies included in the analysis were conducted in Iran Poureslami et al. In regard to developmental neurotoxicity, much information has in fact been published, although mainly as short reports in Chinese that have not been available to most expert committees.

J Med Pest Control. Effect of high-fluoride water on intelligence in children.


Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis

Each critical abstract contains a brief summary of the review methods, results and conclusions followed by a detailed critical assessment neurotoxicify the reliability of the review and the conclusions drawn.

Average IQ scores were significantly lower in high-fluoride group and -iodine than the reference group. Characteristics of the 27 studies included are shown in Table 1 An et al. Large tracts of China have superficial fluoride-rich minerals with little, if any, likelihood of contamination by other neurotoxicants that would be associated with fluoride concentrations in drinking water.

An investigation of intelligence development of children aged 8—14 years in high-fluoride and low-iodine areas. Twenty-eight provinces were affected by fluorosis in China [in Chinese]. Study selection To be included studies had to compare a high fluoride exposure group to a reference exposure group, report IQ scores or other cognitive function measures, and present a measure of the association between fluoride exposure and cognitive function measures. Future research should include detailed individual-level neurotoxicjty on prenatal exposure, neurobehavioral performance, and covariates for adjustment.

Mean IQ score was significantly lower in children who lived in the high-fluoride area than that of children in the reference exposure area both areas also had arsenic exposure.

Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis – RationalWiki

The authors of the revieww meta-analysis published an updated statement on the study in September of that year, [5] underscoring this:. Fluoride in Drinking Water: We specifically targeted studies carried out in rural China that have not been widely disseminated, thus complementing the studies that have been included in previous reviews and risk assessment reports. Most studies were cross-sectional, but this study design would seem appropriate in a stable population where water supplies and fluoride concentrations have remained unchanged for many years.

The average IQ scores was lower in children from high-fluoride and -iodine developmetnal than those from the reference area, but the results were not significant.

On the other hand, neither can it be concluded that no risk is present. We carried out an extensive adn that includes epidemiological studies carried out in China.


Retrieved from ” https: Unless explicitly noted otherwise, all content licensed as indicated by RationalWiki: Finally, the article has no application to fluoride levels in U. CRD commentary This review addressed a relevant public health issue with reasonable broad inclusion criteria.

Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis

Survey of drinking water quality in Jintang County. It was unclear whether action was taken to avoid reviewer neurktoxicity or bias.

An Updated Collection from the Stata Journal. Neither can it be used to demonstrate the harmful effects or complete safety, to be fair of municipal fluoridation as the study is better used revew examine the effects of fluoride poisoning.

Chin Prim Health Care. Developmental neurotoxicity of industrial chemicals. Choisystemtaic 1] Guifan Sun[note 2] Ying Zhang[note 3] and Philippe Grandjean [note 4] [1] that has been mis-cited by anti-fluoridists for years. Average IQ score was lower in children in the high-fluoride group than those jeta-analysis the reference group. The authors noted that there was considerable diversity in the studies, leading to substantial unexplained heterogeneity in the results, which meant that the generalisability of the results was unclear.

Although fluoride exposure showed inverse associations with test scores, the available exposure information did not allow a formal dose—response analysis. Journal List Environ Health Perspect v. More recently published studies gave smaller effect sizes SMD 0. In addition, two studies were published twice, and the duplicates were excluded.

IQ scores of children in the high-fluoride area were lower than those of children in the reference area. I 2 residual