Cotula cinerea Del. belongs to the family Asteraceae. It is widely used in the traditional medicinal system for the treatment of various ailments such as colic. Cotula cinerea Delile [family COMPOSITAE ] (stored under name); Verified by Not on Brocchia kotschyi; Cotula kotschyi; Cotula cinerea; Brocchia cinerea. Abstract: The phytochemical investigation of Cotula cinerea Del. afforded eighteen Keywords: Cotula cinerea Del.; Asteraceae; Flavonoids; Germacranolide.

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The obtained findings for the two cell lines RD and Vero are summarized in Figures 1 and 2respectively.

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Cotula is a genus of flowering plant in the sunflower family. A preliminary phytochemical screening of the Cotula cinerea and Salvia verbenaca extracts showed the presence of polyphenols such as flavonoids and other secondary metabolites.

The results of this study showed thus that Cotula cinerea essential oil and hexane extract showed significant cytotoxic effects against RD and Vero cell lines, respectively, and could be considered as novel source of antitumor agents.

In the case the RD cell line, the lowest IC 50 value Traditional forms of medicine, especially the herbal products deployed for centuries in many parts of the world, could be good alternative for scientific investigation due to their attributes against tumor cell lines. Indexed in Science Citation Index Expanded.

Higher concentrations were needed in the case of Salvia verbenaca extracts which showed the weakest cytotoxic effects. The main constituents of the essential oil are Camphor, Camphene, Alpha-pinene, 3-carene, Thujone, 4-terpineol, Z -betafarnesene and santolinatriene. Prolonged cancer treatment is generally costly to patients and complicates patient follow-up in hospital.

Further studies are obviously needed to elucidate the exact mechanism of Cotula cinerea in cytotoxic activity. In the case of the Corula cell line, the Cotula cinerea hexane extract showed the higher cytotoxic effect followed by the ethyl acetate, the essential oil, and the n -butanol extract.

From Wikipedia, the free encyclopedia. Furthermore, natural products could be as efficient as synthetic ones with no or less toxicity and are less expensive than synthetic drugs.


In this work we were interested in exploring the potential cytotoxicological effect of Cotula cinerea and Salvia verbenaca from Morocco.

Comparison of the obtained results for both cell lines showed that Cotula cinerea extract activity was higher than its corresponding Salvia verbenaca one. The obtained values are correlated with the metabolized intracellular MTT concentrations and are therefore proportional to the number of living cells. Retrieved from ” https: Skip to search form Skip to main content. Correspondence should be addressed to Fatima-Ezzahrae Guaouguaou ; moc.

For both lines, an increase of the cytotoxicity with the concentration of the essential oil or the used extracts was observed indicating a dose dependent effect. Since his account, only a few changes have been made but the number of species has remained more or less stable.

Cotula socialis Hilliard Cotula sororia DC. Our results indicated that Cotula cinerea essential oil and hexane extract showed significant and encouraging cytotoxic effects against RD and Vero cell lines, respectively, and could then be considered as source of novel antitumor agents.

Hilliard Cotula loganii Hutch. Antibacterial activity of silver nanoparticles synthesized by using whole plant extracts of Clitoria ternatea. After 24 h incubation, cells were then treated with the essential oil of Cotula cinerea or its extracts hexane, ethyl acetate, and n -butanol in addition to those of Salvia verbenaca.

Cabrera Cotula microglossa DC. Comparative evaluation of antioxidant and insecticidal properties of essential oils from five Moroccan aromatic herbs. However, and despite all the progress made, the cancer treatment remains a challenging task for both the patients and the medical staff.

Antiproliferative activity at different concentrations of the essential oil and different extracts of Cotula cinerea conerea and Salvia verbenaca bottom against Vero cell line by MTT assay. This study is expected thus to be beneficial for clinical and traditional applications for Cotula cinerea as a remedy against cancer and opens new perspectives for further exploration on other types cineera cancer cell lines. Koch Cotula cinereum Cotula coronopifolia L. References Publications referenced by cinerwa paper.

Results and Discussion In an ongoing program aimed at the exploration of the phytochemical compounds and the biological activities of medicinal plants of Morocco, we were interested, in this work, in the cytotoxic effect of Cotula cinerea and Salvia verbenaca. Gymnogyne Steetz Peyrousea DC. Most are disciform lacking ray florets. The essential oil of Cotula cinerea aerial parts cohula extracted by hydrodistillation using a Clevenger-type apparatus.


In the case of the Vero tumor cell line, Table 1 reveals that Cotula cinerea essential oil showed the highest cytotoxic capacity with the lowest IC 50 value Further investigations regarding the identification of bio-actives molecules responsible for these effects are needed.

The obtained results raise then the possibility of a potential use cotua Cotula cinerea as a source of potent anticancer products. The objective of this work was to investigate the cytotoxicological effect of the extracts hexane, ethyl acetate, and n -butanol of Cotula cinerea and Salvia verbenaca in addition to the essential oil of Cotula cinerea. Cancer is a complex disease caused by several factors such as genetic deregulation, environmental influencing agents, and epigenetic modification factors [ 12 ].

Cotula — Wikipédia

Antiproliferative activity at different concentrations of the essential oil and cjnerea extracts of Cotula cinerea top and Salvia verbenaca bottom against RD cell line by MTT assay. These compounds could explain the cytotoxic effect of this extract on RD tumor cell line. This work was therefore initiated in order to evaluate the in vitro antiproliferative effect of Cotula cinerea and Salvia verbenaca extracts and essential oil against tumor RD and Vero cell lines.

Essential oils are complex molecules containing various and several terpenoids compounds belonging mainly to monoterpene and sesquiterpene chemical groups and presenting different functional groups such as alcohols, phenols, ketone, etc. This was observed for both cell lines. After 30 minutes of incubation at room temperature, absorbance was measured at nm using an ELISA plate reader. These plants are widely used in the Moroccan traditional folk medicine.

Despite the appreciable advancements and progress made in cancer treatment, it continues to constitute a serious global health problem, especially ciberea the appearance of multidrug resistance cells.