The effect of hydro-alcoholic celery (Apium graveolens) leaf extract on cardiovascular parameters and lipid profile in animal model of hypertension induced by. Abstract: Apium graveolens (celery) is an edible and traditionally medicinal plant worldwide, among others for the treatment of hypertension. Celery (Apium graveolens L., Apiaceae) is one of the popular aromatic mean arterial blood pressure and heart rate in normotensive and hypertensive rats.

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Tehran University Medical Journal

Brain nuclear factor-kappa B activation contributes to neurohumoral excitation in angiotensin II-induced hypertension. Hibiscus, widely known as roselle, is used for hypertension, fever, and other diseases in folk medicine. Negative control groups group 7 and 8 received NS 0.

Black tea catechins are converted by an enzymatic polyphenol oxidase and peroxidase oxidative polymerization reaction to tannins: Endothelial dysfunction in human disease.

Moreover, both luteolin Xagorari et al. Conflict of interest statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Indeed, a drop of BP from Support Center Support Center.

Apigenin, a flavone isolate of A. A green tea extract high in catechins reduces body fat and cardiovascular risks in humans.

Anti-hypertensive Herbs and their Mechanisms of Action: Part I

Danshen’s most effective components include: Effects and mechanisms of total Panax notoginseng saponins on graveolena of vascular smooth muscle cells with plasma pharmacology method. Tea consumption enhances endothelial-dependent vasodilation; a meta-analysis.

Author information Article notes Copyright and License information Disclaimer. Thymoquinone TQone of the most abundant and bioactive components in Nigella sativa ‘s seeds, has been identified as the major element in its healing effects Ahmad et al.

Hypertension 1689— The hexanic, methanolic, and aqueous-ethanolic extracts were administered intraperitoneally and their effects on BP and heart rate HR were evaluated in comparison with spirnolactone as a diuretic and positive control. Hypertension is the most common cause of death in the world. A rethinking on the benefits and drawbacks of common antioxidants and a proposal to look for the antioxidants in allium products as ideal agents: Dehkordi and Kamkhah, Other studies have also reported similar antioxidant activities of coriander Cioanca et al.


Papademetriou V, et al. Involvement of Rab28 in NF-kappaB nuclear transport in endothelial cells. The data analysis was performed by Autochro software. In conclusion, celery leaf extract with its blood pressure and lipid lowering effects, can be considered as an antihypertensive agent in chronic treatment of elevated SBP.

Rat isolated aortic rings. Garlic as a natural agent for the treatment of gravellens The authors would like to thank Miss Tuqa Saleh Al Shehabi for her assistance in drawing the figures.

NBP is one of the active constituents in celery. Two of these compounds, luteolin a flavonoid and ethyl caffeate ester of hydroxycinnamic acidexhibit potent anti-inflammatory activities. For evaluation of the persistent effect of celery and spirnolacton, groups 3 and 6 received DOCA, for two more weeks after stopping the administration of drugs graceolens week 7. Effectiveness and tolerability of a standardized extract from Hibiscus sabdariffa in patients with mild to moderate hypertension: Plants contain a bounty of phytochemicals that have proven to be protective by reducing the risk of various ailments and diseases.

Evidently, the rationale for the use of herbal and plant remedies is definitely not surprising, considering the fact that they contain thousands of bioactive components that have known therapeutic applications Pan et al.

Antioxidant and drug detoxification potentials of Hibiscus sabdariffa anthocyanin extract. In a randomized, double-blind, Lisinopril-controlled clinical trial, antihypertensive effects were notable subsequent to treatment with dried extract of calyx mg for 4 weeks in patients with stage 1 or 2 hypertension Herrera-Arellano et al.


Ex vivo study of the vasorelaxant activity induced by phenanthrene derivatives isolated from Maxillaria densa. Cardioprotective effect of saffron extract and safranal in isoproterenol-induced myocardial infarction in wistar rats. Insulin gene expression pattern in rat pancreas during the estrous cycle.

Anti-hypertensive Herbs and their Mechanisms of Action: Part I

Angiotensin II-mediated vascular smooth muscle cell growth signaling. Taking BP medications can cause side effects such as headache, dizziness, tachycardia, feeling tired, and sexual dysfunction. Received Nov 11; Accepted Feb 6. Indeed, the lack hypertensipn sufficient clinical trials constitutes a significant limitation on their use at the present time.

Methanol extract from A. Once the plateau was attained, concentration-response curves of extracts-induced relaxation 0. Unique vascular protective properties of natural products: Chronic administration of aqueous extract of Hibiscus sabdariffa attenuates hypertension and reverses cardiac hypertrophy in 2K-1C hypertensive rats. This action was not influenced apoum either methylene blue, endothelial denudation, indomethacin, nifedipine, or caffeine, and the concentration of intracellular signaling molecules cAMP, cGMP, and inositol monophosphate were unaltered Ko et al.

Antihypertensive Effect of Celery Seed on Rat Blood Pressure in Chronic Administration

Annals of the New York Academy of Sciences, 1: The results indicated that all extracts decreased BP and increased the HR in hypertensive rats, but had no effect on normotensive rats. Hepatoprotective action of celery Apiumgraveolens leaves in acetaminophen-fed freshwater fish Pangasiussutchi.

Rat isolated pulmonary arteries. Protective effect of extract of Crataegus pinnatifida pollen on DNA damage response to oxidative stress.

Ang II induces aldosterone production Oparil et al.