Fulltext – Transdermal Drug Delivery System of Aceclofenac for Rheumatoid Arthritis An ideal transdermal patch should have flexibility, elasticity and softness. Formulation and biopharmaceutical evaluation of a transdermal patch containing aceclofenac. Rhee YS(1), Nguyen T, Park ES, Chi SC. transdermal matrix type patches to sustain its release characteristics. Key Words: Aceclofenac, Transdermal drug delivery, HPMC, Ethyl.

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Formulation and evaluation of transdermal patch of aceclofenac | Grishma Patel –

The transdermal films prolonged the drug release up to 24 h thereby minimizing the dosage frequency unlike the conventional oral drug delivery. These polymers were then dissolved in solvent spread in petri dish previously coated with a lubricant system containing water: The ratio of the polymers was kept constant.

It was concluded that the transdermal films of aceclofenac have the great potential for the treatment of aceclorenac.

Development and in-vitro evaluation of diltiazem hydrochloride transdermal patches based on povidone-ethyl patxhes matrices. The ex vivo permeation study in the modified Franz diffusion apparatus through excised rat abdominal skin in pH 7. Controlled Drug Delivery Fundamentals and Applications 2nd ed. In vivo study Primary skin irritation test: Moreover, the use of penetration enhancers like limonene and Span 20 may bring the radical improvement in the drug flux.


The percentage of moisture content was calculated as the difference between initial and final weight with respect to final weight.

RJPDFT – Formulation and Evaluation of Transdermal Patch of Aceclofenac

Here, formulated patches were wrapped in aluminium foil and kept at room Procedure adopted for evaluation of formulation after temperature for a period of 30 days.

After activation the silica gel-coated TLC plates were developed for the drug excipients and their physical mixture in the mobile phase of hydrochloric acid: Thickness of each individual patch the patch Kg.

The other side of cellulose nitrate membrane was towards the Drug Content Uniformity: The average in percentage of drug contents of three films was noted. Investigation of effects of terpene skin penetration enhancers on stability and biological activity of lysozyme.

Formulation and biopharmaceutical evaluation of a transdermal patch containing aceclofenac.

Formulated patches were attached with the centre of the patch. Solvent evaporation method generally provides products with good percentage of drug content. Different combinations of polymers are as methanol used in the study were of analytical grade. To the group IV standard 0.

Transdermal patch of 3. Weights required to break the which on a large part determines patient acceptability patch was noted. In d-limonene and Span containing films F3 and F5, respectively was found to be showing higher drug release as compared to their other formulations.

Result of all evaluation carried out in order to detect irritation and parameters was found to be satisfactory within sensitization under conditions of maximal stress which permissible limits. The coxibs, selective inhibitors of cyclooxygenase Sorbitan monolaurate 20 as a potential skin permeation enhancer in transdermal patches.


After 12 h of shaving, non-medicated patch was applied to the group I control using an adhesive tape USP. To assess the irritant effect or any chance of edema with the use of transdermal patches, primary skin irritancy test was performed.

These data are in good tune with the ex vivo permeation study. Skip to main content. Various chemical agents act as permeation enhancers.

In this study, each batch. Increasing the concentration increased the drug permeation in both the cases. The mean value of three readings and standard deviation of folding endurance the number of times, the film could be folded at the same place without breaking were shown in Table 2.

A nonionic surfactant-Span and a terpene d limonene were taken as enhancers.

Article Tools Print this article. The enhanced permeation of the drug across the skin showed greater anti-inflammatory activity which can lead to greater to antiarthritic activity. Amount of drug entrapped receptor compartment having phosphate buffer.